Human Skin Regenerated on Immunodeficient Mice after Transplantation of Cultured Human Skin Cells. Human Skin Model.
نویسندگان
چکیده
منابع مشابه
Human Skin Equivalent Model
Skin, the largest organ in the body, performs many important roles including protection against physical and chemical insults, regulation of temperature and fluid loss, and immunity and sensory roles. Once damaged, skin cannot perform these normal tasks and numerous complications such as infection or fluid loss can occur. To restore these roles, the body needs to close the wound as quickly as p...
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The recent era of exploring the human microbiome has provided valuable information on microbial inhabitants, beneficials and pathogens. Screening efforts based on DNA sequencing identified thousands of bacterial lineages associated with human skin but provided only incomplete and crude information on Archaea. Here, we report for the first time the quantification and visualization of Archaea fro...
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Autologous engineered skin substitutes (ESS) have been shown to close excised, full-thickness burns, but are consistently hypopigmented due to depletion of human melanocytes (hM) during culture of keratinocytes. Hypothetically, addition of hM to ESS may restore uniform pigmentation, but may also promote neoplasia and tumor formation. To evaluate this risk, 16 strains of hM were isolated and pro...
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Bioengineered skin substitutes can facilitate wound closure in severely burned patients, but deficiencies limit their outcomes compared with native skin autografts. To identify gene programs associated with their in vivo capabilities and limitations, we extended previous gene expression profile analyses to now compare engineered skin after in vivo grafting with both in vitro maturation and norm...
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ژورنال
عنوان ژورنال: Proceedings of The Japanese Society of Animal Models for Human Diseases
سال: 1997
ISSN: 0918-8991,1884-4197
DOI: 10.1538/expanim1992.13.24